The group of Philipp Wild has extensive experience in systems medicine research with a focus on cardiovascular disease. The team has been coordinating the population-representative Gutenberg Health Study (GHS, N=15,010) since 2007 and the MyoVasc study on heart failure (N=3,289) since 2013. Both studies include comprehensive, sequential biosampling and boast over 10,000 high-quality variables per individual per clinical visit, covering deep (sub)clinical phenotyping as well as lifestyle and environmental factors. Moreover, longitudinally collected multi-omics data spanning the genotype, methylome, transcriptome and proteome are available in both studies.
All collected blood samples undergo highly standardized pre-analytical processing following established SOPs, and are stored in the BioBank Mainz of the University Medical Center. This state-of-the-art automated biobanking facility is managed by the group, and houses more than 10 million liquid and cell samples. This rich biorepository is the backbone of the DIASyM research core.
Within the DIASyM project, newly generated mass spectrometric omics datasets are integrated into the highly granular databases of GHS and MyoVasc. State-of-the-art biostatistics, machine learning and bioinformatics are applied to analyze and interpret these unique datasets of high complexity. By integrating the molecular data with (sub)clinical information on the heart failure syndrome, novel pathophysiological insights will be obtained, bringing the goal of precision medicine in heart failure closer to clinical reality.